Pancakes

Consistent Multi-Protocol Image Segmentation Across Biomedical Domains

Marianne Rakic
MIT CSAIL & MGH
Siyu Gai
MIT CSAIL & MGH
Etienne Chollet
MIT CSAIL & MGH
John V. Guttag
MIT CSAIL
Adrian V. Dalca
MIT CSAIL & HMS MGH

NeurIPS 2025

Pancakes

Consistent Multi-Protocol Image Segmentation Across Biomedical Domains

Marianne Rakic
MIT CSAIL & MGH
Siyu Gai
MIT CSAIL & MGH
Etienne Chollet
MIT CSAIL
John Guttag
MIT CSAIL
Adrian V. Dalca
MIT CSAIL & HMS, MGH

Neurips 2025

Overview


We introduce a new challenging task: for unseen biomedical domains, generate label maps from multiple protocols that are consistent across subjects.

Pancakes addresses it through a protocol-sampling mechanism and outperforms foundation segmentation models.

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Intro


There are many ways (protocols) to segment a biomedical image. The region you want to segment often depends on the downstream tasks.

Therefore, it is useful to produce multiple plausible segmentation maps. What we care three aspects:

Accuracy: What is the overlap between the ground truth and the prediction?

Consistency: Are label maps from the same protocols yielding the same structures with the same labels for different images?

Diversity: Can the model generate a wide choice of different label maps?

Method



We introduce a new challenging task: for unseen biomedical domains, generate label maps from multiple protocols that are consistent across subjects. Pancakes addresses it through a protocol-sampling mechanism and outperforms foundation segmentation models. Check our paper if you are curious :)

Visualizations




Pancakes produces consistent label maps. Each color corresponds to a different label ID.

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Pancakes produces diverse label maps.
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Citation


If you find our work or any of our materials useful, please cite our paper:

@inproceedings{rakic2025pancakes,
  title={Pancakes: Consistent Multi-Protocol Image Segmentation Across Biomedical Domains},
  author={Marianne Rakic and Siyu Gai and Etienne Chollet and John V. Guttag and Adrian V. Dalca},
  booktitle={Advances in Neural Information Processing Systems},
  year={2025},
}